Tranilast exerts pleiotropic effects on stellate cells, kupffer cells and hepatocytes. Tranilast inhibited activation of stellate cells and development of hepatic fibrosis. It prevented development of hepatic steatosis. It suppressed hepatic expression of TGF-beta. Tranilast inhibited the intrahepatic recruitment of Kupffer cells and the production of TNF-alpha in a dietary animal model of NASH. It also suppressed oxidative stress. Tranilast Prevents the Progression of Experimental Diabetic Nephropathy through Suppression of Enhanced Extracellular Matrix Gene Expression.

To access the rest of the information on this page,
Log In or sign up for a free B-Bridge account: