Field
Health Care, Medicine, Biotechnology
Keywords
DDS, Alveolar Macrophage, Diagnostic Product, Respiratory Disease, Lung Cancer, Asthma, Tuberculosis

Abstracts
Disclosed is a drug delivery particle which comprises a substance to be delivered, a biodegradable polymer and a phospholipid in an amount of 1 to 5% by mass relative to the total mass of the particle, and which can be prepared by spray-drying. Also disclosed is a method for production of a drug delivery particle, which comprises spray-drying a dispersion or solution containing a substance to be delivered, a biodegradable polymer and a phospholipid in an amount of 1 to 5% by mass relative to the total mass of the particle. The drug delivery particle can be used for the transpulmonary administration of a substance.

Advantages
According to this invention, it can reach to an alveolus efficiently transpulmonary, and an alveolar macrophage can be selectively provided with the drug delivery particles which can send a drug to be sent.


Inventor
Prof. Kimiko Makino, Takehisa Nakajima et al.
(Tokyo University of Science)


Patent Publication No
(APPLICATION NUMBER, FILING DATE)WO2007057912 (Apr. 10, 2007)
(PUBLICATION NUMBER, PUBLICATION DATE)WO2007119724 (Oct.25, 2007)
(PRIORITY APPLICATION NUMBER, PRIORITY DATE)JP2006-111294 (Apr. 13, 2006) 
JP, 2007-284362, A (Nov. 1, 2007)

Internal file number
G2007-001 (T2005-134)

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