Field
Synthesis Approach, Chemical Reaction, Production
Keywords
Pyridine Oxide Compound, Carboxylic Acid Derivative, Optically Active Carboxylic Acid Derivative, Production


Abstracts
Pyridine oxide compounds of general formula (I), optically active forms thereof, and their salts or hydrates; and performed in the presence of any of these as a catalyst,
(1) a process for producing an ester or amide compound from a carboxylic acid equivalent and an alcohol or amine,
(2) an asymmetric esterification reaction, and
(3) an asymmetric amidation reaction.
[Chemical formula 1]
wherein R<1>s may be identical with or different from each other and each is an alkyl, an aromatic ring group, a heterocyclic group, carboxyl, ester, cyano, a halogen atom, an oxygen atom, a sulfur atom or a nitrogen atom; R<2>s may be identical with or different from each other and each is a hydrogen atom, an alkyl, an aromatic ring group, a heterocyclic group, carboxyl, ester, cyano, a halogen atom, an oxygen atom, etc.; and R<3>s and R<4>s may be identical with or different from each other and each is a hydrogen atom, an alkyl, an aromatic ring group, a heterocyclic group, carboxyl, ester, cyano, a halogen atom, an oxygen atom, etc.


Advantages
If the compound of this invention is used as a catalyst, ester or an amide compound can be manufactured advantageously.


Inventor
Prof. Isamu Shiina  (Tokyo University of Science)


Patent Publication No
(APPLICATION NUMBER, FILING DATE)
WO2006302830 (Feb.17, 2006), US11/816562 (Feb.17, 2006), JP2007-503745 (Feb. 17, 2006)
(PUBLICATION NUMBER, PUBLICATION DATE)
WO2006088132 (A1), JP, 2006-088132, A1 (Aug. 24, 2006), US2009-0062548 (Mar. 5, 2009) (DATE OF REQUEST FOR EXAMINATION)Jan. 29, 2009 (JP)
(PRIORITY APPLICATION NUMBER, PRIORITY DATE)
JP2005-0042832 (Feb.18, 2005)


Internal file number
G2005-006, T2007-059, (T2004-084)

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