The inventors have developed novel thionucleoside-s-nitrosyl derivatives, oligonucleotides capable of specifically transferring a nitrosyl group to a targeted nucleotide, and a method to chemically induce specific point mutations in a target gene sequence.  Oligonucleotides containing novel nitrosyl derivatives are synthesized by nitrosylating nucleotides that have thiocarbonyl substitutions of their  carbonyl group.  Oligonucleotides containing these modified nucleotides are able to transfer the nitrosyl group in a base-specific manner when hybridized to a specific sequence. 

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