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High-Yielding Synthesis of the Anti-influenza Neuramidase Inhibitor (-)-Oseltamivir via Three "One-Pot" Operations
Inexpensive synthesis process for "Tamiflu", new influenza medicine
Field
Medicine, Biotechnology
Keywords
Oseltamivir, Synthesis, Anti-Influenza, Enantioselective Michael Reaction
Advantages
High-Yielding Synthesis of (-)-Oseltamivir via Three "One-Pot" Operations
Inventor
Prof. Yujiro Hayashi, Assistant Prof. Hayato Ishikawa
(Tokyo University of Science)
Patent Publication No
(APPLICATION NUMBER, FILING DATE)
WO2009059789 (May 28, 2009)
(PRIORITY APPLICATION NUMBER, PRIORITY DATE)
1.JP2008-143226 (May 30, 2008) ,
2.JP2008-311543 (Dec. 5, 2008)
Publication
1) Review: M. Shibasaki, M. Kanai, Eur. J. Org. Chem. 2008, 1839.
2) Y. Hayashi, H. Gotoh, T. Hayashi, M. Shoji, Angew. Chem. Int. Ed. 2005, 44, 4212.
Internal file number
G2009-001 (T2007-152, T2008-092)
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