Field
     Medical drug, Screening method
Keywords
     Fluorescent molecular probe, Screening method, Screening kit, Drug candidate compound


Advantages
This invention relates to the art that controls the oil temperature of the hydraulic oil of the automatic transmission in the vehicles that carry an automatic transmission especially about the control device carried in vehicles.

Abstract
Disclosed are a method for analyzing the interaction between a target protein and a compound using a compound capable of interacting with the target protein and capable of emitting fluorescent light natively which has been selected previously; an apparatus for use in the analysis; and a kit for use in the analysis. A method for screening a compound capable of interacting with a target molecule comprising the steps of: performing the competitive reaction between a fluorescent molecular probe and candidate compounds for binding to the target molecule, in which the probe used is a ligand which is capable of binding to the target molecule and is capable of emitting fluorescent light natively without the need of fluorescent labeling; and selecting a compound which has competed with the fluorescent molecular probe by means of fluorescence analysis.

Inventor
    Prof. Seiichi Tanuma, Atushi Yoshimori (Tokyo University of Science)


Patent Publication No
     (APPLICATION NUMBER, FILING DATE)
     WO2005024274 (Dec.28, 2005), JP2006-550880 (Dec.28, 2005)
     (PUBLICATION NUMBER, PUBLICATION DATE)
     WO2006070941 (A1) (Jul. 6, 2006), JP, 2006-070941, A1 (Jul. 6, 2006)

Publication
"A new fluorescent probe for zinc: an 8-hydroxy-5-N, N-dimethylaminosulfonylquinoline-pendant1,4,7,10-teraazacyclododecane”, Aoki S, Sakurama K, Matsuo N, Yamada Y, Takasawa R, Tanuma S, Shiro M, Takeda K, Kimura E,  CHEMISTRY, December 2006


Internal file number
G2005-002

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