Keywords 
     Nanocomposite Particle, DDS, Biodegradable Polymer, Diagnostic Product,
     Biologically Active Agent, Asthma, Tuberculosis, Caner, Hypertension


Advantages
     According to this invention, it has good solubility to water, and when water is made to contact,
     the nano composite particles, which show good, redispersibility can be provided.

Abstract
Disclosed is a nanocomposite particle having good solubility and redispersibility in water. Specifically disclosed is a nanocomposite particle composed of a nanoparticle containing a drug to be delivered and a biodegradable polymer, and a sugar material. The sugar material is composed of a disaccharide, and the mass ratio between the nanoparticle and the disaccharide is within the range of from 40:60 to 60:40.

　　　　　
　　　　　* FPF (Fine Particle Fraction)
　　　　　The FPF is value suitable used for evaluating the degree of delivery to the alveoli,
　　　　　and larger the FPF the more excellent the delivery to the alveoli becames.


Inventor
    Prof. Kimiko Makino, Prof. Hiroshi Terada et al. (Tokyo University of science)


Patent publication No
     (APPLICATION NUMBER, FILING DATE)
     JP2007-011484 (Jan. 22, 2007),  WO2006055388 (Mar. 16, 2007), US12/282956 (Mar. 16, 2007), EP07738833.8 (Mar. 16, 2007)
     (PUBLICATION NUMBER, PUBLICATION DATE)
     JP, 2007-277220, A (Oct. 25, 2007), WO2007111163 (Oct. 4, 2007), US20090169637 (Jul. 2, 2009), EP2005968 (Dec. 24, 2008)

Publication
Keishiro Tomoda, Takumi Ohkoshi, Keiji Hirota, Ganeshchandra S. Sonavane, Takehisa Nakajima, Hiroshi Terada, Masahito Komuro, Kenji Kitazato, Kimiko Makino, “Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer”, COLLOIDS AND SURFACES B-BIOINTERFACES, May 2009Keishiro Tomoda, Takumi Ohkoshi, Takehisa Nakajima, Kimiko Makino,  “Preparation and properties of inhalable nanocomposite particles: Effects of the size, weight ratio of the primary nanoparticles in nanocomposite particles and temperature at a spray-dryer inlet upon properties of nanocomposite particles”, COLLOIDS AND SURFACES B-BIOINTERFACES, 2008


Internal file number
G2006-012, T2006-142 (T2005-125)

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