Field
     Production method

Keywords
     2-hydroxy ester intermediate, 1,2-diol intermediate, 2-amino alcohol intermediate

Advantages
     Production method of enantiomer. 2-hydroxy ester intermediate, 1,2-diol intermediate,
     2-amino alcohol intermediate

Abstract
Disclosed is a method for producing an optically active carboxylic acid ester directly from a racemic secondary alcohol and a carboxylic acid. Also disclosed is a method for optically resolving a racemic secondary alcohol in the same method as the above-mentioned method. One of the enantiomers of a racemic secondary alcohol and a carboxylic acid are subjected to the dehydrative condensation in the presence of benzoic anhydride or a derivative thereof by using (-)-tetramisole, (+)-tetramisole, (-)-benzotetramisole, (+)-benzotetramisole or the like as an asymmetric esterification catalyst, thereby producing an optically active carboxylic acid ester; and the other of the enantiomers, which is unreacted, is optically resolved.

    

Inventor
     Prof. Isamu Shiina, Dr. Kenya Nakata　(Tokyo University of Science)


Patent Publication No
     (APPLICATION NUMBER, FILING DATE)
     WO2008058743（May 12, 2008）, JP2009-514165 (May 12, 2008)
      (PUBLICATION NUMBER, PUBLICATION DATE)
     WO2008140074（Nov. 20, 2008）, JP2008-140074 (Aug. 5, 2010)


Internal file number
     LSP:95
     G2008-004, T2009-066 (T2007-072, T2007-132)

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