Field
     Medicinal drug, agrichemical, aroma chemical, food additive, chemical products,
     optical material, production method

Keywords
     Optically active 2-hydroxy ester, intermediate compound, carboxylic acid anhydride,
     carboxylic acid, dichloromethane, diethyl ether


Abstract
Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a carboxylic acid anhydride, or a carboxylic acid anhydride and a carboxylic acid. In particular, in the case where the solvent contains a carboxylic acid anhydride, but does not contain a carboxylic acid, as the carboxylic acid anhydride, a carboxylic acid anhydride containing a tertiary or quaternary carbon atom in the a-position is used. On the other hand, in the case where the solvent contains a carboxylic acid anhydride and a carboxylic acid, as the carboxylic acid, a carboxylic acid containing a tertiary or quaternary carbon atom in the a-position is used.


Inventor
     Prof. Isamu Shiina et al.　(Tokyo University of Science)


Patent Publication No
     (APPLICATION NUMBER, FILING DATE)
     WO2010053789 (Mar. 8, 2010)
     (PUBLICATION NUMBER, PUBLICATION DATE)
     WO2010104034 (Sep.16, 2010)


Internal file number
     LSP:102
     G2009-022 (T2008-120, T2009-048)

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